The role and uses of antibodies in COVID-19 infections: a living review
David Oliver Scourfield, Sophie Reed, Max Quastel, Jennifer Alderson, Valentina M T Bart, Alicia Teijeira Crespo, Ruth Jones, Ellie Pring, Felix Clemens Richter, David Ahern, Hannah Almuttaqi, Dominic S. Alonzi, Aljawharah Alrubayyi, Ghada Alsaleh, Valentina M T Bart, Vicky Batchelor, R. Bayliss, Dorothée L. Berthold, Jelena S. Bezbradica, Tehmina Bharuchq, Helene Borrmann, Mariana Borsa, Rowie Borst, Juliane Brun, Stephanie Burnell, Lorenzo Capitani, Athena Cavounidis, Lucy Chapman, Anne Chauveau, Liliana Cifuentes, Amy Codd, Ewoud B. Compeer, Clarissa Coveney, Amy Cross, Sara Danielli, Luke C. Davies, Calliope A. Dendrou, Sandra Dimonte, Ruban Rex Peter Durairaj, Lynn B. Dustin, Arthur Dyer, Ceri A. Fielding, Fabian Fischer, Awen Gallimore, Sarah Galloway, Anís N. Gammage, Ester Gea‐Mallorquí, Andrew Godkin, Stephanie Hanna, Cornelia Heuberger, Sarah L. Hulin-Curtis, Fadi Issa, Emma Jones, Ruth Jones, Kristin Ladell, Sarah N. Lauder, Kate Liddiard, Petros Ligoxygakis, Fangfang Lu, Bruce J. MacLachlan, Shayda Maleki-Toyserkani, Elizabeth H. Mann, Anna M. Marzeda, R. James Matthews, Julie M. Mazet, Anita Milicic, Emma Mitchell, Owen Moon, Van Dien Nguyen, Miriam O’Hanlon, Clara Eléonore Pavillet, Dimitra Peppa, Ana Pires, Eleanor Pring, Max Quastel, Sophie Reed, Jan Rehwinkel, Niamh Richmond, Felix Clemens Richter, Alice Robinson, Patrícia R S Rodrigues, Pragati Sabberwal, Arvind Sami, Raphael Sanches Peres, Quentin J. Sattentau, Barbora Schonfeldova, David Oliver Scourfield, T. Selvakumar, Freya R Shepherd, Cariad Shorten, Anna Katharina Simon, Adrian L. Smith, Alicia Teijeira Crespo, Michael Tellier, Emily Thornton, Lion F. K. Uhl, Erinke van Grinsven, A.K. Wann, Richard Williams, Joseph D. Wilson
Abstract
Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity.