<i>In situ</i>visualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging
Yongqing Zhou, Ping Li, Xin Wang, Chuanchen Wu, Nannan Fan, Xiaoning Liu, Lijie Wu, Wei Zhang, Wen Zhang, Zhenzhen Liu, Bo Tang
Abstract
We report a novel near-infrared fluorescence/photoacoustic imaging method for peroxisomal viscosity, enabling an accurate diagnosis and drug evaluation of non-alcoholic fatty liver disease.
Topics & Concepts
Fatty liverPeroxisomeFluorescenceIn situViscosityAlcoholic liver diseaseFluorescence-lifetime imaging microscopyInfraredChemistryPathologyMaterials scienceMedicineDiseaseBiochemistryInternal medicineOpticsPhysicsGeneOrganic chemistryCirrhosisComposite materialLiver Disease Diagnosis and TreatmentAdipose Tissue and MetabolismLipid metabolism and biosynthesis