Transition-Metal-Free Radical-Triggered Hydrosulfonylation and Disulfonylation Reaction of Substituted Maleimides with Sulfonyl Hydrazides
Hong‐Li Ruan, Yilin Ma, Ke-Xin Man, Sheng‐Yin Zhao
Abstract
A convenient and practical hydrosulfonylation and disulfonylation of substituted maleimides was realized using sulfonyl hydrazides as the sulfur reagent and tert-butyl hydroperoxide as the oxidant. The advantages of the reactions include mild and transition-metal-free reaction conditions, good functional group tolerance, and readily available starting materials. The radical species-induced pathway is also demonstrated by mechanistic studies.
Topics & Concepts
ChemistrySulfonylReagentRadical initiatorTransition metalSulfurFree-radical reactionFunctional groupCombinatorial chemistrySulfoneFree-radical additionOrganic chemistryReaction conditionsRadicalCatalysisPolymerPolymerizationAlkylSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions