WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8
Lei Zhou, Yun Zhong, Fan Wang, Yi Guo, Rui Mao, Hongfu Xie, Yiya Zhang, Ji Li
Abstract
, overexpression of WTAP evidently increased senescence cells in skin and induced skin aging. In summary, these findings revealed the critical role of WTAP-mediated m6A modification in skin aging and identified ELF3 as an important target of m6A modification in HDFs senescence, providing a new idea for delaying the aging process.
Topics & Concepts
SenescenceGene knockdownCell biologyBiologyDownregulation and upregulationRNACell cultureBiochemistryGeneticsGeneRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation