Iodine-Mediated C2,3–H Aminoheteroarylation of Indoles
Maoyi Dai, Yingying Zhang, Xiaoxiang Zhang, Ruiyi Wang, Wanxing Wei, Zhuan Zhang, Taoyuan Liang
Abstract
A metal-free one-pot oxidative cross-dehydrogenation coupling reaction for the formation of C-N/C-C bonds at the C2,3-positions of indoles with azoles and quinoxalinones has been developed. The proposed method has several notable features, including metal-free catalysis, the use of N-H free indoles as substrates, ease of operation, mild reaction conditions, and compatibility with a wide range of substrates.
Topics & Concepts
DehydrogenationCatalysisIodineChemistryCompatibility (geochemistry)Combinatorial chemistryCoupling reactionReaction conditionsMetalOxidative coupling of methaneOrganic chemistryMaterials scienceComposite materialCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation