Self-assembled dipeptide based fluorescent nanoparticles as a platform for developing cellular imaging probes and targeted drug delivery chaperones
Subramaniyam Sivagnanam, Kiran Das, Madhuri Basak, Tarun Mahata, Adele Stewart, Biswanath Maity, Priyadip Das
Abstract
to specifically deliver Dox to cancer cells while sparing the myocardium, a major source of dose-limiting adverse events in the clinic. Our work represents an important proof-of-concept exercise demonstrating that ultra-short peptide-based fluorescent nanostructures have great promise for the development of new imaging probes and targeted drug delivery vehicles.
Topics & Concepts
AptamerDrug deliveryBiocompatibilityDoxorubicinNanotechnologyCancer cellChemistryBiophysicsPeptideFluorescenceIn vivoTargeted drug deliveryMaterials scienceBiochemistryCancerMolecular biologyMedicineBiologySurgeryChemotherapyOrganic chemistryQuantum mechanicsBiotechnologyInternal medicinePhysicsSupramolecular Self-Assembly in MaterialsAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranostics