Lower Lactate Levels and Lower Intracellular pH in Patients with <i>IDH</i>-Mutant versus Wild-Type Gliomas
Katharina J. Wenger, Joachim P. Steinbach, Oliver Bähr, Ulrich Pilatus, Elke Hattingen
Abstract
BACKGROUND AND PURPOSE: Preclinical evidence points toward a metabolic reprogramming in isocitrate dehydrogenase (IDH) mutated tumor cells with down-regulation of the expression of genes that encode for glycolytic metabolism. We noninvasively investigated lactate and Cr concentrations, as well as intracellular pH using 1 H/phosphorus 31 ( 31 P) MR spectroscopy in a cohort of patients with gliomas.
Topics & Concepts
Intracellular pHIsocitrate dehydrogenaseIntracellularIDH1MedicineGliomaIn vivo magnetic resonance spectroscopyMutantNuclear magnetic resonanceNuclear medicineChemistryMolecular biologyBiochemistryBiologyMagnetic resonance imagingCancer researchGeneEnzymeRadiologyPhysicsGlioma Diagnosis and TreatmentAdvanced MRI Techniques and ApplicationsMRI in cancer diagnosis