Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia
Katie Hege-Hurrish, Xinan Qiao, Xinyu Li, Yongwei Su, Jenna L. Carter, Jun Ma, Hasini A. Kalpage, Maik Hüttemann, Holly Edwards, Guan Wang, Seongho Kim, Alan A. Dombkowski, Xun Bao, Jing Li, Jeffrey W. Taub, Yubin Ge
Topics & Concepts
Myeloid leukemiaCancer researchPI3K/AKT/mTOR pathwayBiologyReprogrammingMyeloidLeukemiaTranscriptomeClofarabineVenetoclaxOxidative phosphorylationApoptosisPharmacologyImmunologyCytarabineCellGeneBiochemistryGene expressionChronic lymphocytic leukemiaAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors ResearchCancer, Hypoxia, and Metabolism