Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
Nicole P. Hachmann, Jessica Miller, Ai‐ris Y. Collier, John D. Ventura, Jingyou Yu, Marjorie Rowe, Esther A. Bondzie, Olivia Powers, Nehalee Surve, Kevin Hall, Dan H. Barouch
Abstract
To the Editor: In recent months, multiple lineages of the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, 1 with subvariants BA.1 and BA.2 showing substantial escape from neutralizing antibodies. 2-5 Subvariant BA.2.12.1 is now the dominant strain in the United States, and BA.4 and BA.5 are dominant in South Africa (Fig. Subvariants BA.4 and BA.5 have identical sequences of the spike protein.
Topics & Concepts
TiterSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)NeutralizationNeutralizing antibodyVirologySpike ProteinCoronavirus disease 2019 (COVID-19)AntibodyMedicine2019-20 coronavirus outbreakOutbreakImmunologyVirusInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesCOVID-19 Clinical Research Studies