The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection
Danelle Weakland, Sara N. Smith, Bailey A. Bell, Ashootosh Tripathi, Harry L. T. Mobley
Abstract
Serratia marcescens is a bacterium frequently found in the environment, but over the last several decades it has evolved into a concerning clinical pathogen, causing fatal bacteremia. To establish such infections, pathogens require specific nutrients; one very limited but essential nutrient is iron. We sought to characterize the iron acquisition systems in S. marcescens isolate UMH9, which was recovered from a clinical bloodstream infection. Using RNA sequencing (RNA-seq), we identified two predicted siderophore gene clusters ( cbs and sch ) that were regulated by iron.
Topics & Concepts
Serratia marcescensBiologySiderophoreMicrobiologyBacteremiaBloodstream infectionPathogenVirulenceSerratiaHuman pathogenBacteriaGeneAntibioticsEscherichia coliGeneticsPseudomonasBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingAntibiotic Resistance in Bacteria