Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus <i>Talaromyces</i> sp. HDN1820200
Yi Zhao, Chunxiao Sun, Luyao Huang, Xiao Zhang, Guojian Zhang, Qian Che, Dehai Li, Tianjiao Zhu
Abstract
Six new nonadride derivatives, named talarodrides A–F (1–6), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1–4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5 and 6 possess the first case of a naturally occurring 5/7/6 methanocyclonona[c]furan skeleton. Talarodride A (1) and talarodride B (2) showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus with MICs of 3.13–12.5 μM.