Initiation and severity of experimental pancreatitis are modified by phosphate
Ahmad Farooq, Liliana Hernández, Sandip M. Swain, Rafiq A. Shahid, Joelle Romac, Steven R. Vigna, Rodger A. Liddle
2022American Journal of Physiology-Gastrointestinal and Liver Physiology13 citationsDOIOpen Access PDF
Abstract
Impaired ATP synthesis disrupts acinar cell homeostasis and is an early step in pancreatitis. We report that reduced phosphate availability impairs mitochondrial function and worsens pancreatic injury. Phosphate supplementation improves mitochondrial function and protects against experimental pancreatitis, raising the possibility that phosphate supplementation may be useful in treating pancreatitis.
Topics & Concepts
PancreatitisPhosphatePancreatic functionMitochondrionFunction (biology)HomeostasisInternal medicinePancreatic injuryEndocrinologyChemistryMedicineBiologyBiochemistryCell biologyPancreatitis Pathology and TreatmentErythrocyte Function and PathophysiologyNeonatal Health and Biochemistry