Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening
Xu Zhang, Xuening Chen, Lian Lu, Qianqian Fang, Chun Liu, Zhonghui Lin
Topics & Concepts
Small moleculeHolliday junctionChemistryFörster resonance energy transferDNAEndonucleaseHigh-throughput screeningHeLaCleavage (geology)SerineHomologous recombinationPhosphorylationMolecular biologyBiochemistryBiologyIn vitroFluorescencePaleontologyQuantum mechanicsFracture (geology)PhysicsDNA Repair MechanismsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry