A trustworthy CpG nanoplatform for highly safe and efficient cancer photothermal combined immunotherapy
Ming Jiang, Jinjia Zhang, Yiran Shi, Wangheng Yang, Jingchao Li, Duo Sun, Sijin Xiang, Xiaolan Chen, Lanfen Chen, Nanfeng Zheng
Abstract
). Importantly, the combination therapy induced tumor cell death and released tumor-associated antigens, which could be effectively taken up and presented by antigen presenting cells with the assistance of CpG, leading to increased TNF-α and IL-6 production and enhanced cytotoxic T lymphocyte (CTL) activity. This work provides a new paradigm of utilizing photothermal nanomaterials for safe and highly efficient cancer photothermal combined immunotherapy.
Topics & Concepts
Photothermal therapyTrustworthinessCancer immunotherapyImmunotherapyCpG siteCancerNanotechnologyMaterials scienceCancer researchComputer scienceMedicineChemistryInternet privacyDNA methylationInternal medicineGene expressionBiochemistryGeneNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesAdvanced biosensing and bioanalysis techniques