Electroactive scaffolds of biodegradable polyurethane/polydopamine-functionalized graphene oxide regulating the inflammatory response and revitalizing the axonal growth cone for peripheral nerve regeneration
Qiao Zhang, Jinlin Chen, Yuan Ping Feng, Jingjing Lin, Jiehua Li, Yanchao Wang, Hong Tan
Abstract
study of sciatic nerve transection injury, WPU/pGO NGSs were found to regulate the immune microenvironment by activating macrophage M2 polarization and upregulate growth-associated protein 43 (GAP43) to facilitate axonal elongation. Histological and motor function analysis demonstrated that WPU/pGO NGSs had a neuroprosthetic effect close to that of an autograft, which significantly promoted the regeneration of myelinated axons, reduced gastrocnemius atrophy, and enhanced hindlimb motor function. These findings together suggested that electroactive WPU/pGO NGSs may represent a safe and effective strategy to manage large nerve defects.
Topics & Concepts
Regeneration (biology)Materials scienceGraphenePolyurethanePeripheral nerveNanotechnologyComposite materialCell biologyAnatomyMedicineBiologyGraphene and Nanomaterials ApplicationsNerve injury and regenerationElectrospun Nanofibers in Biomedical Applications