B‐cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T‐cell precursor acute lymphoblastic leukaemia/lymphoma (ETP‐ALL/LBL) from other subtypes of T‐cell ALL/LBL
Hong Fang, Wei Wang, Siba El Hussein, Kiyomi Morita, Hannah C. Beird, Akash Mitra, Sanam Loghavi, Pei Lin, Elias Jabbour, Joseph D. Khoury
Abstract
B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0·009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.