Harnessing Autophagic Network Is Essential for Trophoblast Stem Cell Differentiation
Shreeta Chakraborty, Rumela Bose, Safirul Islam, Shreya Das, Rupasri Ain
Abstract
upon differentiation. In addition, inhibition of autophagy was associated with a decrease in nuclear size of TGCs. Taken together, these data highlight that autophagy is a necessary prelude in commitment of trophoblast differentiation from the multipotent TS cells probably by regulating protein turnover at the onset of differentiation.
Topics & Concepts
AutophagyBiologyCell biologyAutophagosomeTrophoblastCellular differentiationStem cellPlacentaGeneticsApoptosisFetusGenePregnancyAutophagy in Disease and TherapyEpigenetics and DNA MethylationToxoplasma gondii Research Studies