Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia
Chiara Pedicone, Sandra Fernandes, Alessandro Matera, Shea T. Meyer, Stewart N. Loh, Jeung‐Hoi Ha, Denzil Bernard, John D. Chisholm, Rosa Chiara Paolicelli, William G. Kerr
Abstract
in an LPS-induced endotoxemia assay. Finally, we show that K306 enhances phagolysosomal degradation of synaptosomes and dead neurons by microglia revealing a novel function for SHIP1 that might be exploited therapeutically in dementia.
Topics & Concepts
MicrogliaAgonistChemistryReceptorCell biologyPhagocytosisInflammationBiologyBiochemistryImmunologySphingolipid Metabolism and SignalingLipid Membrane Structure and BehaviorEndoplasmic Reticulum Stress and Disease