Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing
Heng Sun, Jianming Zeng, Zhengqiang Miao, Kuan Cheok Lei, Chen Huang, Lingling Hu, Sek Man Su, Un In Chan, Kai Miao, Xu Zhang, Aiping Zhang, Sen Guo, Si Chen, Ya Meng, Min Deng, Wenhui Hao, Haipeng Lei, Ying Lin, Zhonglin Yang, Dongjiang Tang, Koon Ho Wong, Xiaohua Douglas Zhang, Xiaoling Xu, Chu‐Xia Deng
Abstract
Our study provides a useful resource for better understanding of mammary tumorigenesis induced by BRCA1 deficiency.
Topics & Concepts
CarcinogenesisCancer researchMammary tumorBiologyMammary glandTranscriptomeOncogeneCell growthCellCancerPathologyCell cycleBreast cancerGeneMedicineGene expressionGeneticsCancer Genomics and DiagnosticsBRCA gene mutations in cancerSingle-cell and spatial transcriptomics