Complementary early-phase magnetic particle imaging and late-phase positron emission tomography reporter imaging of mesenchymal stem cells <i>in vivo</i>
Nourhan Shalaby, John J. Kelly, Olivia C. Sehl, Julia J. Gevaert, Matthew S. Fox, Qi Qi, Paula J. Foster, Jonathan D. Thiessen, Justin W. Hicks, Timothy J. Scholl, John A. Ronald
Abstract
= 0.9817). We report the first use of combined MPI and PET for cell tracking and show the complementary benefits of MPI for sensitive detection of MSCs early after implantation and PET for longer-term measurements of cell viability.
Topics & Concepts
Bioluminescence imagingMesenchymal stem cellPositron emission tomographyMolecular imagingSodium-iodide symporterStem cellReporter geneMagnetic particle imagingIn vivoMagnetic resonance imagingPreclinical imagingMedicineNuclear medicineBiomedical engineeringMaterials sciencePathologyChemistryCell cultureTransfectionRadiologyBiologyNanotechnologyMagnetic nanoparticlesGene expressionCell biologyNanoparticleLuciferaseSymporterGeneGeneticsBiotechnologyTransporterBiochemistryCharacterization and Applications of Magnetic NanoparticlesMicrofluidic and Bio-sensing TechnologiesGeomagnetism and Paleomagnetism Studies