Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology
Xiaoke Di, Meiyu Wan, Ya-nan Bai, Fengjuan Lu, Minghui Zhao, Zhifei Zhang, Yang Li
Topics & Concepts
IcariinKEGGTropomyosin receptor kinase BPharmacologyNeurotrophic factorsPI3K/AKT/mTOR pathwayAntidepressantCREBBrain-derived neurotrophic factorMedicineChemistryBioinformaticsInternal medicineBiologySignal transductionTranscription factorReceptorGene expressionTranscriptomeBiochemistryHippocampusGenePathologyAlternative medicineMedicinal Plant Pharmacodynamics ResearchCytokine Signaling Pathways and InteractionsPharmacological Effects of Natural Compounds