Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain
Tamás Kiss, Ádám Nyúl‐Tóth, Jordan DelFavero, Priya Balasubramanian, Stefano Tarantini, Janet Faakye, Rafał Gulej, Chetan Ahire, Anna Ungvari, Andriy Yabluchanskiy, Graham B. Wiley, Lori Garman, Zoltán Ungvári, Anna Csiszár
Topics & Concepts
SenescenceTranscriptomeWhite matterGrey matterMicrogliaBiologyNeuroinflammationAging brainCognitive declineGene expressionCell biologyGene expression profilingNeurosciencePathologyGeneInflammationDementiaImmunologyMedicineGeneticsCognitionRadiologyMagnetic resonance imagingDiseaseTelomeres, Telomerase, and SenescenceNeuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics