Immunomodulatory extracellular vesicles: an alternative to cell therapy for COVID-19
Ashim Gupta, Shivaji Kashte, Sachin Kadam, Manu Gupta, Hugo C. Rodriguez, Anish G. Potty, Saadiq F. El‐Amin, Nicola Maffulli
Abstract
: Clinical trials using extracellular vesicles are registered against COVID-19 associated complications, with some evidence of safety and efficacy. Extracellular vesicles present an alternative potential for cell therapy for COVID-19 management, but further preclinical and clinical investigations are needed.
Topics & Concepts
Cytokine stormARDSMicrovesiclesMedicineExtracellular vesicleExtracellular vesiclesImmunologyExtracellularCell therapyMesenchymal stem cellStem cellPathologyCoronavirus disease 2019 (COVID-19)BiologyCell biologyInternal medicineLungmicroRNADiseaseBiochemistryGeneInfectious disease (medical specialty)Extracellular vesicles in diseaseLong-Term Effects of COVID-19COVID-19 Clinical Research Studies