Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics
Lizhen He, Li‐Xuan Cai, Meng-Hua Li, Guang‐Lu Zhang, Li‐Peng Zhou, Tianfeng Chen, Mei‐Jin Lin, Qing‐Fu Sun
Abstract
a spontaneous deprotonation self-assembly process. Brilliant chemical stability and singlet oxygen production ability of this emissive octanuclear organopalladium macrocycle make it a good candidate toward biological studies. After cellular uptake by endocytosis, the metallacycle exhibits potent fluorescence cell imaging properties and cancer photodynamic therapeutic ability through enhancing ROS production, with high biocompatibility and safety. This study not only provides a rational design strategy for highly stable luminescent organopalladium metallacycles, but also sheds light on their application in imaging-guided photodynamic cancer therapy.