Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria
Štefan Schwarz, Wanjiang Zhang, Xiang‐Dang Du, Henrike Krüger, Andrea T. Feßler, Shizhen Ma, Yao Zhu, Congming Wu, Jianzhong Shen, Yang Wang
Abstract
Seven mobile oxazolidinone resistance genes, including cfr , cfr (B), cfr (C), cfr (D), cfr (E), optrA , and poxtA , have been identified to date. The cfr genes code for 23S rRNA methylases, which confer a multiresistance phenotype that includes resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A compounds. The optrA and poxtA genes code for ABC-F proteins that protect the bacterial ribosomes from the inhibitory effects of oxazolidinones.
Topics & Concepts
GramGram-negative bacteriaBacteriaGeneMicrobiologyGram-positive bacteriaBiologyMobile genetic elementsGeneticsEscherichia coliPlasmidProbiotics and Fermented FoodsAntibiotic Resistance in BacteriaMicrobial Community Ecology and Physiology