The Relationship between HDAC3 and Malignant Tumors: A Mini Review
Lou Tong, Haotian Liang, Huiyu Zhuang, Chongdong Liu, Zhenyu Zhang
Abstract
Histone deacetylases 3 (HDAC3) is a member of the histone deacetylases family. This family is associated with cellular physiological function, such as signal transduction, cell cycle, proliferation, apoptosis, and cardiac development. HDAC3 plays an important role in the progression of malignant tumors, especially in terms of proliferation, apoptosis, metastasis, angiogenesis, and anticancer drug resistance. This review discusses the basic elements of HDAC3 and the relationship between HDAC3 and malignant tumors.
Topics & Concepts
HDAC3Cancer researchApoptosisAngiogenesisCell growthMetastasisHistoneSignal transductionChemistryBiologyCell biologyMedicineHistone deacetylaseInternal medicineCancerGeneticsDNAHistone Deacetylase Inhibitors ResearchComputational Drug Discovery Methods