Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi‐Karimata, Naoki Sugimoto, Daisuke Miyoshi
Abstract
We constructed a minimum liquid–liquid phase separation model system using only G-quadruplex-forming oligonucleotides and cationic oligopeptides. Moreover, droplet redissolution was achieved in a sequence-specific manner.
Topics & Concepts
Sequence (biology)G-quadruplexChromatographyPhase (matter)ChemistryLiquid phaseLiquid liquidComputational biologyDNABiologyBiochemistryPhysicsOrganic chemistryThermodynamicsRNA Research and SplicingRNA and protein synthesis mechanismsRNA Interference and Gene Delivery