Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis
Preeti Kumari, Valencia Fernandes, Anika Sood, Islauddin Khan, Dharmendra Kumar Khatri, Shashi Bala Singh
Topics & Concepts
LipotoxicityNecroptosisMicrogliaNeuroinflammationCognitive declineInternal medicineEndocrinologyProgrammed cell deathNeuroprotectionDownregulation and upregulationMedicineBiologyChemistryInsulinInsulin resistanceApoptosisInflammationBiochemistryDementiaGeneDiseaseNeuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersinterferon and immune responses