An iron-containing ferritin-based nanosensitizer for synergistic ferroptosis/sono-photodynamic cancer therapy
Yilin Zheng, J. P. Zheng, Manyi Du, Ya Yang, Xudong Li, Haijun Chen, Yu Gao
Abstract
with DHA and by simultaneously irradiation of FCD with both light and ultrasound. More importantly, the depletion of GSH by FCD could decrease glutathione peroxidase 4 (GPX4) and increase lipid peroxidation (LPO) levels, thereby inducing ferroptosis. Therefore, by integrating the advantageous GSH-depletion capacity, ROS generation ability, and ferroptosis induction capability into one single nanosystem, FCD can serve as a promising platform for combined chemo-sono-photodynamic therapy of cancer.
Topics & Concepts
Reactive oxygen speciesPhotodynamic therapyFerritinGPX4Hydrogen peroxideGlutathioneLipid peroxidationChemistryCancer researchCancer cellLipid peroxideProgrammed cell deathApoptosisCancerOxidative stressBiochemistryGlutathione peroxidaseBiologyEnzymeGeneticsOrganic chemistryNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseAdvanced Nanomaterials in Catalysis