Pyrazine Derivatives—Versatile Scaffold
Nazia Tambat, Sana Mulani, Azma Haryaty Ahmad, Siraj B. Shaikh, Khursheed Ahmed
Abstract
Abstract Pyrazines are important class of pharmacophores because of their versatility in pharmacological activity. Pyrazines are among the most widely known heterocyclic compounds those can be isolated from natural sources or produced synthetically. Many substituted pyrazines are produced naturally and are widely distributed in plants, animals, including marine organisms. These heterocyclic analogs have been proven important scaffold in perfumeries, food industries and pharmaceuticals. Due to diverse biological activities of pyrazine-based drugs, a rise in investigations of pyrazine containing candidates has been observed. In recent past numerous advancement has been taken place to explore their synthetic pathways and biological activities. This review focuses on biosynthesis of different pyrazine derivatives and their various biological activities.