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EZH2-H3K27me3-Mediated Epigenetic Silencing of DKK1 Induces Nucleus Pulposus Cell Pyroptosis in Intervertebral Disc Degeneration by Activating NLRP3 and NAIP/NLRC4

Qijun Yao, Lei Yue, Yongxu Zhang, Haoran Chen, Xiaowei Dong, Zhiqiang Ye, Haidong Liang

2024Inflammation8 citationsDOI

Topics & Concepts

Cell biologyPyroptosisGene silencingDegeneration (medical)ChemistryBiologyApoptosisMedicineProgrammed cell deathPathologyBiochemistryGeneSpine and Intervertebral Disc PathologySpinal Hematomas and ComplicationsGout, Hyperuricemia, Uric Acid
EZH2-H3K27me3-Mediated Epigenetic Silencing of DKK1 Induces Nucleus Pulposus Cell Pyroptosis in Intervertebral Disc Degeneration by Activating NLRP3 and NAIP/NLRC4 | Litcius