Lenvatinib and Cu<sub>2−<i>x</i></sub>S nanocrystals co-encapsulated in poly(<scp>d</scp>,<scp>l</scp>-lactide-<i>co</i>-glycolide) for synergistic chemo-photothermal therapy against advanced hepatocellular carcinoma
Qi Xu, Qiuting Li, Zhe Yang, Piao Huang, Han Hu, Zhimin Mo, Zizhen Qin, Zushun Xu, Tianyou Chen, Shengli Yang
Abstract
Lenvatinib (LT) and copper sulfide nanocrystals (Cu 2− x S NCs) were co-encapsulated in poly( d , l -lactide- co -glycolide) (PLGA). Both in vitro and in vivo evaluations demonstrated that Cu 2− x S NCs enhanced the anticancer efficacy of LT, without recurrence.
Topics & Concepts
Photothermal therapyNanocrystalMaterials scienceLactideNuclear chemistryChemical engineeringNanotechnologyChemistryCopolymerPolymerComposite materialEngineeringNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisQuantum Dots Synthesis And Properties