High mutation load, immune-activated microenvironment, favorable outcome, and better immunotherapeutic efficacy in melanoma patients harboring MUC16/CA125 mutations
Qinghua Wang, Yichen Yang, Meng Yang, Xiangchun Li, Kexin Chen
Abstract
mutations was associated with a better response rate and survival outcome in male patients but not in female or overall patients. These findings provide new implications for tailoring immunotherapeutic strategies for melanoma patients.
Topics & Concepts
MutationImmune systemMelanomaImmunotherapyMedicineCancer researchImmunologyBiologyGeneticsGeneCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responsesvaccines and immunoinformatics approaches