The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction
Pierre Nottelet, Laure Bataille, Géraldine Gourgues, Robin Anger, Carole Lartigue, Pascal Sirand‐Pugnet, Esther Marza, Rémi Fronzes, Yonathan Arfi
Abstract
domains is twisted out of alignment, disrupting the antigen binding site. We also show that MIB-MIP has the ability to promote the dissociation of the antibody-antigen complex. This system is functional in cells and protects mycoplasmas from antibody-mediated agglutination. These results highlight the key role of the MIB-MIP system in immunity evasion by mycoplasmas through an unprecedented mechanism, and open exciting perspectives to use these proteins as potential tools in the antibody field.
Topics & Concepts
AntigenAntibodyDissociation (chemistry)ChemistryImmunologyCell biologyBiologyPhysical chemistryMicrobial infections and disease researchGalectins and Cancer BiologyParasitic Infections and Diagnostics