Glomerular C4 deposition and glomerulosclerosis predict worse renal outcomes in Chinese patients with IgA nephropathy
Yan Yang, Xi Tang, Yuan Yang, Xinrui Li, Lingzhi Li, Kai Huang, Yi Li, Jing Li, Ping Fu
Abstract
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is a clinical and pathological syndrome with heterogenous manifestation and progression. Complement activation is involved in the disease. However, the clinical significance of C4 deposition in IgAN is obscure. METHODS: A multicenter retrospective study was conducted in biopsy-proven IgAN patients. Based on mesangial C4 deposition, patients were divided into two groups. The baseline clinical data and immunopathological phenotypes were compared. The composite endpoint was defined as eGFR decline greater than 50%, doubling of baseline serum creatinine, the occurrence of end-stage renal disease (ESRD). RESULTS: < 0.01) as independent risk factors for poor renal outcomes. CONCLUSIONS: Glomerular mesangial C4 deposition and global sclerosis are independent predictors for poor prognosis in IgAN patients.