A brain glioma gene delivery strategy by angiopep-2 and TAT-modified magnetic lipid-polymer hybrid nanoparticles
Lanxin Qiao, Yu Qin, Yaxin Wang, Yi Liang, Dunwan Zhu, Wei Xiong, Lu Li, Di Bao, Linhua Zhang, Xu Jin
Abstract
The gene delivery system can penetrate the BBB model efficiently and transfect C6 glioma cells effectively in magnetic field.
Topics & Concepts
TransfectionChemistryGene deliveryZeta potentialNanoparticleBiocompatibilityTransactivationPenetration (warfare)Reporter geneMagnetic nanoparticlesGliomaBiophysicsNanotechnologyCancer researchMaterials scienceGeneBiochemistryGene expressionBiologyOrganic chemistryEngineeringOperations researchRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery