Ag<sub>2</sub>O-catalysed nucleophilic isocyanation: selective formation of less-stable benzylic isonitriles
Taiga Yurino, Yuji Tange, Ryutaro Tani, Takeshi Ohkuma
Abstract
Both primary and secondary benzylic isonitriles were exclusively produced by the Ag<sub>2</sub>O-catalysed reaction of benzylic phosphates and trimethylsilyl cyanide without formation of the thermodynamically favoured regioisomers, benzylic nitriles.
Topics & Concepts
ChemistryPrimary (astronomy)Trimethylsilyl cyanideCyanideNucleophileStructural isomerTrimethylsilylMedicinal chemistryOrganic chemistryCatalysisAstronomyPhysicsChemical Synthesis and ReactionsChemical Synthesis and AnalysisMulticomponent Synthesis of Heterocycles