Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
Uthpala Seneviratne, Zhen Huang, Christopher W. am Ende, Todd W. Butler, Leah Cleary, Erica C. Dresselhaus, Edelweiss Evrard, Ethan L. Fisher, Michael Green, Christopher J. Helal, John M. Humphrey, Lorraine F. Lanyon, M. Marconi, Paramita Mukherjee, Simone Sciabola, Claire M. Steppan, Emily Sylvain, Jamison B. Tuttle, Patrick R. Verhoest, Travis T. Wager, Longfei Xie, Gayathri Ramaswamy, Douglas S. Johnson, Martin Pettersson
Topics & Concepts
Photoaffinity labelingLiver X receptorChemistryChemical biologyLigand (biochemistry)Small moleculeApolipoprotein EProteomicsBiochemistryReceptorNuclear receptorGeneTranscription factorPathologyDiseaseMedicineCholesterol and Lipid MetabolismDrug Transport and Resistance Mechanismsinterferon and immune responses