Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity
Shaosong Yang, Tiejian Nie, Hua She, Kai Tao, Fangfang Lu, Yiman Hu, Lu Huang, Lin Zhu, Dayun Feng, Dan He, Jing Qi, Thomas Kukar, Long Ma, Zixu Mao, Qian Yang
Abstract
; CDK5: cyclin-dependent kinase 5; CDK5R1: cyclin dependent kinase 5 regulatory subunit 1; CR: calorie restriction; FUDR: 5-fluorodeoxyuridine; HSP90AA1: heat shock protein 90 alpha family class A member 1; MAP1LC3: microtubule associated protein 1 light chain 3; NB: novobiocin sodium; SQSTM1: sequestosome 1; TFEB: transcription factor EB; WT: wild type.
Topics & Concepts
TFEBAutophagyBiologyCell biologyMechanistic target of rapamycinNRF1Transcription factorBAG3Basic helix-loop-helix leucine zipper transcription factorsGeneticsGeneDNA-binding proteinApoptosisGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyHeat shock proteins research