XT-type DNA hydrogels loaded with VEGF and NGF promote peripheral nerve regeneration <i>via</i> a biphasic release profile
Songyang Liu, Yijun Liu, Liping Zhou, C. Li, Meng Zhang, Fengshi Zhang, Zhentao Ding, Yongqiang Wen, Peixun Zhang
Abstract
results indicated a better effect of DNA gel + VEGF/NGF on promoting repair of long defect PNI than the hollow chitin conduits (CT), DNA gel or VEGF/NGF group. The new technology invention holds promising clinical application prospects for repairing PNI and may be used broadly after step-by-step improvement.
Topics & Concepts
Nerve growth factorSelf-healing hydrogelsRegeneration (biology)Vascular endothelial growth factorChemistryNerve guidance conduitTissue engineeringIn vitroIn vivoCell biologyDNA synthesisBiomaterialVEGF receptorsBiomedical engineeringCancer researchBiologyBiochemistryMedicinePolymer chemistryBiotechnologyReceptorOrganic chemistryNerve injury and regenerationRNA Interference and Gene DeliveryElectrospun Nanofibers in Biomedical Applications