Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells
Yi Wen, Hansen Chen, Lu Zhang, Meiling Wu, Feng Zhang, Dan Yang, Jiangang Shen, Jianping Chen
Topics & Concepts
GPX4Lipid peroxidationNADPH oxidaseGlutathioneReactive oxygen speciesOxidative stressCancer cellChemistryGlutathione peroxidaseBiochemistryPharmacologyBiologyCancerEnzymeGeneticsFerroptosis and cancer prognosisPharmacological Effects of Natural CompoundsGenomics, phytochemicals, and oxidative stress