CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway
Tsung‐Ming Chang, Yao‐Chang Chiang, Chiang‐Wen Lee, Chieh‐Mo Lin, Mei-Ling Fang, Miao‐Ching Chi, Ju‐Fang Liu, Yu Ru Kou
Abstract
This study is the first to reveal the function of CXCL14 in promoting EMT and metastasis in lung cancer. As a specific receptor for CXCL14 in lung cancer, ACKR2 mediates CXCL14-induced signaling that leads to cell motility. Our findings can be used as a prognostic biomarker of lung cancer metastasis.
Topics & Concepts
CXCL14Cancer researchLung cancerMetastasisBiologyCancerCell migrationCancer cellAutocrine signallingChemokine receptorChemokineReceptorImmunologyMedicinePathologyCellInflammationGeneticsBiochemistryChemokine receptors and signalingCytokine Signaling Pathways and InteractionsCancer Mechanisms and Therapy