Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
Marta Michalska‐Sionkowska, Oliwia Warżyńska, Beata Kaczmarek, Krzysztof Łukowicz, Anna M. Osyczka, Maciej Walczak
Abstract
Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials' extracts improved the HaCaT cells' viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.