Isothiourea-Catalyzed Atroposelective N-Acylation of Sulfonamides
Jun‐Yang Ong, Xiao Qian Ng, Shenci Lu, Yu Zhao
Abstract
We report herein an atroposelective N-acylation of sulfonamides using a commercially available isothiourea catalyst, (S)-HBTM, with a simple procedure. The N-sulfonyl anilide products can be obtained in good to high enantiopurity, which represents a new axially chiral scaffold. The application of the product as a chiral iodine catalyst is also demonstrated for the asymmetric α-oxytosylation of propiophenone.
Topics & Concepts
ChemistryAcylationPropiophenoneCatalysisSulfonylCombinatorial chemistryOrganic chemistryKetoneAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySphingolipid Metabolism and Signaling