Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation
Kui Wu, Nathan A. Yee, Sangeetha Srinivasan, Amir Mahmoodi, Michael Zakharian, José M. Mejía Oneto, Maksim Royzen
Abstract
The Click Activated Protodrugs Against Cancer (CAPAC) platform uses click chemistry to activate cytotoxic drugs directly at a target site with minimal toxicity, overcoming limitations of conventional chemotherapy and traditional targeted therapies.
Topics & Concepts
In vivoGemcitabinePaclitaxelDoxorubicinCancer researchClick chemistryCytotoxicityPharmacologyCancerBioorthogonal chemistryDrugChemistryMedicineChemotherapyIn vitroBiologyBiochemistryInternal medicineCombinatorial chemistryBiotechnologyClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisMonoclonal and Polyclonal Antibodies Research