Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP‐IV and microbiota
Haihong Chen, Wei Li, Weiguo Hu, Junyu Liu, Canyang Zhang, Yi Wang, Chong Zhang, Xizhen Zhang, Shuo Chen, Qixing Nie, Xin‐Hui Xing
Abstract
AI-driven and computation-based high-throughput methods were developed to mine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hemp seed proteins. The identified peptide VAMP demonstrates a glucose-lowering effect through dual mechanisms: inhibition of DPP-IV activity and selective promotion of intestinal Akkermansia muciniphila growth.
Topics & Concepts
TetrapeptideGlucose homeostasisHomeostasisChemistryMedicineBiologyCell biologyBiochemistryInsulinEndocrinologyInsulin resistancePeptideDiabetes Treatment and ManagementDiet, Metabolism, and DiseaseNatural Antidiabetic Agents Studies