Bioorthogonal control of the phosphorescence and singlet oxygen photosensitisation properties of iridium(<scp>iii</scp>) tetrazine complexes
Peter Kam‐Keung Leung, Lawrence Cho‐Cheung Lee, Herman Ho-Yin Yeung, Kai‐Wa Io, Kenneth Kam‐Wing Lo
Abstract
In this work, we demonstrate bioorthogonal control of the phosphorescence and singlet oxygen photosensitisation properties of new iridium(iii) tetrazine complexes by different reaction partners; the system was exploited for organelle-specific staining and modulated photocytotoxic activity applications.
Topics & Concepts
TetrazinePhosphorescenceBioorthogonal chemistryIridiumSinglet oxygenChemistryCombinatorial chemistryPhotochemistrySinglet stateOxygenFluorescenceOrganic chemistryCatalysisClick chemistryPhysicsQuantum mechanicsNuclear physicsExcited stateClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesbioluminescence and chemiluminescence research