A protein-conjugated photosensitizer with mitochondrial targeting for enhanced photodynamic therapy
Mingwan Shi, Wei Pan, Peng Gao, Yuanyuan Chen, Kaiye Wang, Na Li, Bo Tang
Abstract
A protein-conjugated photosensitizer with mitochondrial targeting ability was synthesized to enhance the therapeutic effects of PDT. The ROS produced by the photosensitizer under laser irradiation could effectively destroy key intracellular proteins and disrupt mitochondrial redox homeostasis, thereby causing mitochondrial dysfunction and irreversible cell death.
Topics & Concepts
PhotosensitizerPhotodynamic therapyConjugated systemChemistryMitochondrionBiophysicsPhotochemistryCancer researchMedicineBiochemistryBiologyOrganic chemistryPolymerNanoplatforms for cancer theranosticsATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism