Translation regulation in response to stress
Thomas D. Williams, Adrien Rousseau
Abstract
Cell stresses occur in a wide variety of settings: in disease, during industrial processes, and as part of normal day-to-day rhythms. Adaptation to these stresses requires cells to alter their proteome. Cells modify the proteins they synthesize to aid proteome adaptation. Changes in both mRNA transcription and translation contribute to altered protein synthesis. Here, we discuss the changes in translational mechanisms that occur following the onset of stress, and the impact these have on stress adaptation.
Topics & Concepts
ProteomeTranslation (biology)Adaptation (eye)Protein biosynthesisCellular adaptationMessenger RNACell biologyCellular stress responseBiologyProtein expressionTranslational regulationTranscription (linguistics)Computational biologyFight-or-flight responseBioinformaticsNeuroscienceGeneticsGeneLinguisticsPhilosophyRNA modifications and cancerRNA Research and SplicingEndoplasmic Reticulum Stress and Disease