p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Eeva‐Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu
Abstract
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
Topics & Concepts
BiogenesisAutophagosomeOxidative stressAutophagyCell biologyOxidative phosphorylationChemistryBiologyBiochemistryApoptosisGeneAutophagy in Disease and TherapyStudies on Chitinases and ChitosanasesSirtuins and Resveratrol in Medicine